Allogeneic transplantation of umbilical cord-derived mesenchymal stem cells for diffuse alveolar hemorrhage in systemic lupus erythematosus
Identifieur interne : 001434 ( Main/Exploration ); précédent : 001433; suivant : 001435Allogeneic transplantation of umbilical cord-derived mesenchymal stem cells for diffuse alveolar hemorrhage in systemic lupus erythematosus
Auteurs : Dongyan Shi [République populaire de Chine] ; Dandan Wang [République populaire de Chine] ; Xia Li [République populaire de Chine] ; Huayong Zhang [République populaire de Chine] ; Nan Che [République populaire de Chine] ; Zhimin Lu [République populaire de Chine] ; Lingyun Sun [République populaire de Chine]Source :
- Clinical Rheumatology [ 0770-3198 ] ; 2012-05-01.
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Abstract
Abstract: Umbilical cord-derived mesenchymal stem cell transplantation (UC-MSCT) has been proved to be effective in the treatment of systemic lupus erythematosus (SLE), based on animal experiments and clinical trials. Diffuse alveolar hemorrhage (DAH) is a rare complication of SLE with a high mortality usually over 50%. This study aimed to assess the efficacy of UC-MSCT in the treatment of SLE-associated DAH. Four SLE patients complicated with DAH, who underwent UC-MSCT, were included. Clinical changes before and after transplantation were assessed by measurements of hemoglobin, platelet level, oxygen saturation, and serological factors. High-resolution CT (HRCT) scans of the chest were performed to evaluate pulmonary manifestation. All the four patients showed dramatic improvements of their clinical manifestations. Hemoglobin was elevated after UC-MSCT and was sustained at a normal level 6 months after UC-MSCT in the four patients. Platelet level was upregulated in two patients who had thrombocytopenia at baseline. Oxygen saturation appeared to be normal at 1 month after UC-MSCT, and this result was confirmed by the HRCT scan of the chest. Serum albumin elevated to 3.5 g/dl 6 months after transplantation. Our findings suggest that UC-MSCT results in amelioration of oxygen saturation as well as hematological and serologic changes, which revealed that UC-MSCT could be applied as a salvage strategy for DAH patients.
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DOI: 10.1007/s10067-012-1943-2
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uniqKey="Sun L" first="Lingyun" last="Sun">Lingyun Sun</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">République populaire de Chine</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Rheumatology</title><title level="j" type="sub">Journal of the International League of Associations for Rheumatology</title><title level="j" type="abbrev">Clin Rheumatol</title><idno type="ISSN">0770-3198</idno><idno type="eISSN">1434-9949</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>London</pubPlace><date type="published" when="2012-05-01">2012-05-01</date><biblScope unit="volume">31</biblScope><biblScope 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Diffuse alveolar hemorrhage (DAH) is a rare complication of SLE with a high mortality usually over 50%. This study aimed to assess the efficacy of UC-MSCT in the treatment of SLE-associated DAH. Four SLE patients complicated with DAH, who underwent UC-MSCT, were included. Clinical changes before and after transplantation were assessed by measurements of hemoglobin, platelet level, oxygen saturation, and serological factors. High-resolution CT (HRCT) scans of the chest were performed to evaluate pulmonary manifestation. All the four patients showed dramatic improvements of their clinical manifestations. Hemoglobin was elevated after UC-MSCT and was sustained at a normal level 6 months after UC-MSCT in the four patients. Platelet level was upregulated in two patients who had thrombocytopenia at baseline. Oxygen saturation appeared to be normal at 1 month after UC-MSCT, and this result was confirmed by the HRCT scan of the chest. Serum albumin elevated to 3.5 g/dl 6 months after transplantation. Our findings suggest that UC-MSCT results in amelioration of oxygen saturation as well as hematological and serologic changes, which revealed that UC-MSCT could be applied as a salvage strategy for DAH patients.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Shi, Dongyan" sort="Shi, Dongyan" uniqKey="Shi D" first="Dongyan" last="Shi">Dongyan Shi</name></noRegion><name sortKey="Che, Nan" sort="Che, Nan" uniqKey="Che N" first="Nan" last="Che">Nan Che</name><name sortKey="Li, Xia" sort="Li, Xia" uniqKey="Li X" first="Xia" last="Li">Xia Li</name><name sortKey="Lu, Zhimin" sort="Lu, Zhimin" uniqKey="Lu Z" first="Zhimin" last="Lu">Zhimin Lu</name><name sortKey="Sun, Lingyun" sort="Sun, Lingyun" uniqKey="Sun L" first="Lingyun" last="Sun">Lingyun Sun</name><name sortKey="Sun, Lingyun" sort="Sun, Lingyun" uniqKey="Sun L" first="Lingyun" last="Sun">Lingyun Sun</name><name sortKey="Wang, Dandan" sort="Wang, Dandan" uniqKey="Wang D" first="Dandan" last="Wang">Dandan Wang</name><name sortKey="Zhang, Huayong" sort="Zhang, Huayong" uniqKey="Zhang H" first="Huayong" last="Zhang">Huayong Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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